Can You Smoke Marijuana While Taking Nyquil?

Beginner Grow Guide is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to If you click on a link on this site that takes you to Amazon, I will earn a small commission and help keep the lights on at no extra cost to you 🙂

Mixing weed and Nyquil sounds like a good time.

And honestly it is.

You’re probably wondering if there are any issues with mixing weed and cough medicine and the answer is no. You can mix weed and cough syrup without any issues.

We’ll break down the various uses and side effects of Nyquil, as well as how it will interact with marijuana if you take both drugs simultaneously.

The Uses and Side Effects of NyQuil

Vicks NyQuil is a popular over-the-counter medication used to relieve common cold and flu symptoms, such as congestion, coughing, and difficulty breathing. Its main active ingredients are:

  • Dextromethorphan (DXM) – a cough suppressant
  • Acetaminophen (Tylenol) – a pain reliever and fever reducer
  • Doxylamine – an antihistamine that treats congestion, sore throat, and sneezing, while also acting as a sleep aid

The main active ingredient that suppresses many of the flu-like symptoms is dextromethorphan, acting to alleviate the coughing often associated with colds and flus. 

The second main ingredient acetaminophen, commonly known as the brand name Tylenol, is a pain reliever and acts to reduce fevers.

The last key ingredient in NyQuil is Doxylamine, an antihistamine that helps to treat congestion, sore throat, and sneezing. Doxylamine also acts as the sleeping aid ingredient in NyQuil, being replaced by Phenylephrine in the day-time equivalent DayQuil.

A man Smoking marijuana

While generally safe, NyQuil can cause side effects, such as drowsiness, dry mouth, nausea, stomach discomfort, blurred vision, dizziness, and lightheadedness. The potential for addiction or abuse is low, but caution is advised when using over-the-counter medications like NyQuil and DayQuil.

Side Effects Of NyQuil

While NyQuil does have the potential for addiction or abuse, most people don’t have any issue with OTC medications like Nyquil/Dayquil. Nyquil can cause some side effects that might overlap with smoking weed (like dry mouth).

If weed makes any of these side effects worse then you might want to back off the weed or not mix it with Nyquil.

They are as follows:

  • Drowsiness
  • Dry mouth, throat, or nose
  • Nausea or vomiting
  • Stomach discomfort
  • Blurred vision
  • Dizziness
  • Lightheaded feeling

Can You Smoke Weed And Use NyQuil At The Same Time?

Because both cannabis and NyQuil are fairly subtle drugs, both with minimal side effects, the risk of a severe drug interaction is minimal and shouldn’t be a cause for concern

However, there are some amplifying effects when combining the two, especially when it comes to the drowsiness you will feel with both drugs.

The sleeping aid in NyQuil, Doxylamine, is the ingredient that helps you feel better when you’re sick with flu-like symptoms.

 If you have ever taken NyQuil over the counter, or a similar product, you can attest to the strength it carries in allowing you to fall asleep where you would normally be kept awake with a bad cough or other symptoms.

Can You Smoke Marijuana While Taking Nyquil?

Many types of cannabis also result in drowsiness, especially with strong Indica strains. Because both carry these effects, you should be wary of combining the two unless you anticipate sleeping relatively soon after intake.

But if you’re goal is to fall asleep and stay asleep, combining Nyquil with a good Indicia strain can be an effective way to sleep through the night when you’re sick. The sedative effect of an Indica strain can make sleeping easier when you’re sick.

Can Nyquil Make Me Feel More High When I Smoke?

Anecdotally some have reported that NyQuil may also amplify the ‘high’ feeling associated with cannabis, however, there isn’t a lot of supporting data for the reasons why or how. It may have to do with the specific strain, with stronger body high variations seeing increased effectiveness.

The drug Dextromethorphan has also been connected to the feeling of being high (which we will expand upon below), however, this is only possible if taking abnormally large doses.

Smoking Cannabis While Sick With A Cold Or Flu

While you may not see any ill effects from mixing cold medicine such as NyQuil and cannabis simultaneously, smoking while sick may have its own set of drawbacks. Because many colds come with breathing complications, smoking can further agitate those issues.

If you have a severe cough, triggering that feeling through traditional smoking via a bong, bowl, or a joint may only worsen the feeling. Some have recommended putting ice in a bong, acting to cool the smoke you inhale and giving you a less harsh hit.

Bong manufacturers have even started including built in ice catchers due to the popularity of this trend, although you will be inhaling more moisture into your lungs while you do. Because of the increased moisture, this may also act to agitate your cough, so your mileage may vary with this method.

Can Weed Replace The Use Of NyQuil?

Because of the overlap in side effects between smoking and the use of NyQuil, some may choose to solely rely on cannabis for the treatment of the symptoms. In general, marijuana will not be nearly as effective as a cold medicine when treating all the symptoms, only helping with the sleep aid aspect.

Can Weed Replace The Use Of NyQuil?

Cannabis may also act as a pain reliever, but it will not be as effective as the acetaminophen found in NyQuil. In general, the pain-relieving effects of cannabis will have a shorter duration, with THC remaining active in your system for a relatively short period of time (however it will remain traceable for quite a bit longer, which you can read about here.)

If you have mild symptoms or just a bit of discomfort, cannabis may be a suitable replacement for NyQuil, although it won’t directly treat any of the symptoms of sickness.

Frequently Asked Questions

Should you smoke marijuana while sick?

In general, it is not recommended to smoke while sick with cold or flu-like symptoms. While it may not have any direct adverse effects on your health, it can act to prolong or agitate symptoms of coughing.

If cannabis is a regular part of your daily routine, replacing smoking with edibles, tinctures, or alternative cannabis products can help.

Can NyQuil Get You High?

If abused, many innocuous drugs can promote the feeling of being ‘high’. When taken in large doses, NyQuil becomes one of those drugs, often mixed into drinks with alcohol.

Pills spilling out of pill bottle

The active ingredient which promotes this feeling is Dextromethorphan, or DMX, which can bring about hallucinations or feelings of euphoria. When these large doses of DMX are taken, the effects are often compared to the illicit drug PCP and is nicknamed “robo-tripping”.

When abused, this can be extremely dangerous, leading to damage of the liver, heart attacks, seizures, or even death. Even if you don’t experience these severe medical conditions, DMX can lead to serious addiction and results in typical symptoms of withdrawal.

Furthermore, accidental addiction can result from nightly use as a sleep aid, so you should remain cautious about the consistent use of NyQuil.